Research Topics

We utilize Synthetic Biology, Cellular Engineering, and Imaging techniques to study:

Cancer stem cell niche in inflammatory breast cancer

Epithelial and immune cell polarity
.

Organelle biogenesis and coupling
.

Dysregulation of intracellular transport

Publications

2015

AR Wolfe, BG Debeb, L Lacerda, RL Larson MS, A Bambhroliya, X Huang, F Bertucci, P Finetti, D Birnbaum, S Van Laere, P Diagaradjan, B Ruffell, NJ Trenton, K Chu, WN Hittelman, MR Diehl, I Levental, NT Ueno, WA Woodward (2015).
"Simvastatin prevents triple-negative breast cancer metastasis in pre-clinical models through regulation of FOXO3a."
Clinical Cancer Research - Submitted.


R. Tyler McLaughlin, MR Diehl, AB Kolomeisky (2015).
"Collective Dynamics of Cytoskeletal Motor Proteins."
Soft Matter - Submitted.



2014

Rogers A, Constantinou PE, Jamison DK, Driver JW, Diehl MR (2014).
"Construction and analyses of elastically coupled multiple-motor systems."
Methods in Enzymology, Volume 540: Chapter 11.


Efremov, A. K., Radhakrishnan, A., Tsao, D. S., Bookwalter, C. S., Trybus, K. M., Diehl, M. R. (2014).
"Delineating cooperative responses of processive motors in living cells."
Proceedings of the National Academy of Sciences,111(3), E334-E343.


Tsao, D. S., & Diehl, M. R. (2014).
"Molecular motors: Myosins move ahead of the pack."
Nature Nanotechnology, 9(1), 9-10.


2013

K. Uppulary, J.W. Driver, M.R. Diehl, A.B. Kolomeisky (2013).
"Analysis of cooperative responses of multiple kinesin motors to structural and chemical factors."
Journal of Cellular and Molecular Bioengineering 6, 38-47.



2012

Diehl, M.R. (2012).
"Templating a Molecular Tug-of-War."
Science 338, 626-627.


Zimak, J., Schweller, R. M., Duose, D. Y., Hittelman, W. N., & Diehl, M. R. (2012).
"Programming in Situ Immunofluorescence Intensities through Interchangeable Reactions of Dynamic DNA Complexes."
ChemBioChem,13(18), 2722-2728.


Schweller, R.M. Zimak, J. Duose, D.Y. Qutub, A.A. Hittelman, W.N. Diehl, M.R. (2012).
"Multiplexed in situ Immunofluorescence via Dynamic DNA Complexes."
Angewandte Chemie International Edition 51, 9292-9296.


Uppulury, K. Efremov, A.K. Driver, J.W. Jamison, D.K. Diehl, M.R. and Kolomeisky, A. (2012).
"How the Interplay Between Mechanical and Non-Mechanical Interactions Affect Multiple Kinesin Dynamics."
The Journal of Physical Chemistry B 116. 8846-8855.


Lu, H. Efremov, A.K. Bookwalter, C.S. Krementsova, E.B. Driver, J.W. Trybus, K.M. Diehl, M.R. (2012).
"Collective Dynamics of Elastically-Coupled Myosin V Motors."
The Journal of Biological Chemistry 287. 27753-27761.


Duose, D.Y. Schweller, R.M. Zimak, J. Rogers, A. Hittelman, W. Diehl, M.R. (2012).
"Configuring Robust DNA Strand Displacement Reactions for In Situ Molecular Analyses."
Nucleic Acids Research 40, 3289-3298.



2011

Jamison, D.K. Driver, J.W. Diehl, M.R. (2011).
"Cooperative Responses of Multiple Kinesins to Variable and Constant Loads."
Journal of Biological Chemistry 287, 3357-3365.


Driver, J.W. Jamison, D.K. Uppulury, K. Rogers, A.R. Kolomeisky, A.B. Diehl, M.R. (2011).
"Productive Cooperation Among Processive Motors Depends Inversely on their Mechanochemical Efficiency."
Biophysical Journal 101, 386-395.



2010

Duose, D.Y. Schweller, R.M. Hittelman, W.N. Diehl, M.R. (2010).
"Multiplexed and Reiterative Fluorescence Labeling via DNA-Circuitry."
Bioconjugate Chemistry 21, 2327-2331.


Jamison, D.K. Driver, J.W. Rogers, A.R. Constantinou, P.E. Diehl, M.R. (2010).
"Two Kinesins Transport Cargo Primarily via the Action of One Motor: Implications for Intracellular Transport."
Biophysical Journal 99, 2967-2977.


Driver, J.W. Rogers, A.R. Jamison, D.K. Das, R.K. Kolomeisky, A.B. Diehl, M.R. (2010).
"Coupling Between Motor Proteins Determines Dynamic Behaviors of Motor Protein Assemblies."
Physical Chemistry Chemical Physics 12, 10398-10405.



2009

Rogers, A.R. Driver, J.W. Constantinou, P.E. Diehl, M.R. (2009).
"Negative Interference Dominates Collective Transport of Kinesin Motors in the Absence of Load."
Physical Chemistry Chemical Physics 11, 4882-4912.


Constantinou, P.E. Diehl, M.R. (2009).
"The Mechanochemistry of Integrated Motor Protein Complexes."
Journal of Biomechanics 43, 31-37.



2008

Schweller, R.M. Constantinou, P.E. Frankel, N.W. Narayan, P. Diehl, M.R. (2008).
"Design of DNA-Conjugated Polypeptide-based Capture Probes for the Anchoring of Proteins to DNA Matrices."
Bioconjugate Chemistry 19, 2304-2307.


Members

Principal Investigator:


Research Assistant Professor:

Volker Schweikhard, PhD
vs20@rice.edu

Multi-scale fluorescence microscopy methods to investigate the functional organization of multi-cellular communities and spatiotemporal dynamics of cell state transitions



Postdocs:


Graduate Students:

David Tsao
david.tsao@rice.edu

Dynamics of sub-cellular processes

Nicholaus Trenton
trenton@rice.edu

Identifying and understanding the cancer stem cell niche in inflammatory breast cancer

Tyler McLaughlin
rtm5@rice.edu

Quantifying organelle life cycle dynamics with synthetic gene systems


Undergraduates: